Three players injured during last weekend's loss to South Africa - Chris Paterson, Thom Evans and Jason White, are omitted. No 8 Simon Taylor, who missed the first two Bank of Scotland Corporate Autumn Tests, is fit again, while also introduced are wingers Simon Webster and Nikki Walker and flanker Alasdair Strokosch, with Rory Lamont switching to full-back.
Scotland coach Frank Hadden said: "There is an element of freshening up the squad and it's also an opportunity to look at certain blends ahead of the Six Nations but, as ever, the selection is about winning the game."
Scotland team to play Canada in the Bank of Scotland Corporate Autumn Test at Pittodrie, Aberdeen, on Saturday 22 November (kick-off 2.45pm)
15 Rory Lamont (Sale Sharks)
14 Simon Webster (Edinburgh)
13 Ben Cairns (Edinburgh)
12 Nick De Luca (Edinburgh)
11 Nikki Walker (Ospreys)
10 Phil Godman (Edinburgh)
9 Mike Blair (Edinburgh) CAPTAIN
1 Allan Jacobsen (Edinburgh)
2 Ross Ford (Edinburgh)
3 Euan Murray (Northampton Saints)
4 Nathan Hines (Perpignan)
5 Jim Hamilton (Edinburgh)
6 Alasdair Strokosch (Gloucester)
8 Simon Taylor (Stade Francais)
7 John Barclay (Glasgow Warriors)
Substitutes
16 Dougie Hall (Glasgow Warriors)
17 Alasdair Dickinson (Gloucester)
18 Matt Mustchin (Edinburgh)
19 Scott Gray (Northampton Saints)
20 Rory Lawson (Gloucester)
21 Dan Parks (Glasgow Warriors)
22 Max Evans (Glasgow Warriors)
Referee: George Clancy (Ireland). Touch-judges: Alan Lewis (Ireland) and Stuart Terheege (England). TMO: Nigel Whitehouse (Wales)