Ryan has won the battle for the loose head berth against Jon Welsh, his clubmate at Glasgow. Another Warrior, Tom Ryder, could be set for his debut off the bench.
The one-off Test against the Wallabies will be played at Newcastle, in Australia's Hunter Valley.
Scotland
15 Stuart Hogg (Glasgow Warriors)
14 Joe Ansbro (London Irish)
13 Nick De Luca (Edinburgh Rugby)
12 Matt Scott (Edinburgh Rugby)
11 Sean Lamont (Scarlets)
10 Greig Laidlaw (Edinburgh Rugby)
9 Mike Blair (Edinburgh Rugby)
1 Ryan Grant (Glasgow Warriors)
2 Ross Ford (Edinburgh Rugby) CAPTAIN
3 Euan Murray (Newcastle Falcons)
4 Alastair Kellock (Glasgow Warriors)
5 Richie Gray (Glasgow Warriors)
6 Alasdair Strokosch (Gloucester)
7 Ross Rennie (Edinburgh Rugby)
8 John Barclay (Glasgow Warriors)
Substitutes
16 Scott Lawson (Gloucester)
17 Jon Welsh (Glasgow Warriors)
18 Tom Ryder (Glasgow Warriors)
19 Richie Vernon (Sale Sharks)
20 Chris Cusiter (Glasgow Warriors)
21 Duncan Weir (Glasgow Warriors)
22 Tom Brown (Edinburgh Rugby)