A win will keep the Scotstoun men at the top of the league table, and it will also ensure Gregor Townsend's side clinch a home semi-final before the visit of Ulster in their final game of the season on Saturday week.
And Chris Fusaro says the Warriors are determined to get the job done at the Liberty Stadium. He told the Evening Times: "All our focus is on this game, getting a win and that home semi-final.
"Last year, playing against Munster at Scotstoun, with 10,000 people there, the atmosphere was electric and something we are determined to repeat this year. It is a huge advantage. We are massively focused on the Ospreys - to do the job there and continue the momentum we have been building
"We had a good win over Cardiff and then a good win over Connacht, and though the performances have not been where we want them to be, we have analysed everything and going into the last three weeks - four weeks if we reach the final - these small details are the ones that matter."