Gordon Reid will make his 100th appearance for Glasgow Warriors as he continues at loose-head following the bonus point win in Parma last weekend, with Zander Fagerson coming in at tight-head and Fraser Brown keeping his place at hooker.
Fresh from signing a new contract with Glasgow through until May 2019, Stuart Hogg returns at full-back, with Italian international Leonardo Sarto coming in on the right wing and Rory Hughes will make his European debut for the club on the opposite side.
Alex Dunbar and Sam Johnson combine in midfield, with Finn Russell returning at fly-half and Henry Pyrgos coming back in at scrum-half.
Tim Swinson returns from injury and will partner Jonny Gray in the engine room, after the Scotland international was rested last weekend.
Robert Harley moves from second-row to blind-side flanker, with Ryan Wilson and Josh Strauss switching places, with Ryan starting at open-side and Josh at Number 8.
BT Sport Scottish Rugby Academy duo Matt Fagerson and Lewis Wynne are named amongst the replacements and could make their European debuts for the club.
The game is a complete sell out with a capacity crowd of 7,351 expected at Scotstoun tomorrow night.
Glasgow Warriors head coach Gregor Townsend said: "The European Rugby Champions Cup is a brilliant tournament to be involved in and an opportunity for us to play the best teams in Europe.
"Leicester have been one of Europe's leading sides for a number of years and we know they'll provide a tough test tomorrow night.
"But there is a lot of excitement within our squad and we're looking forward to opening our campaign at home in front of a sold out Scotstoun."
15 Stuart Hogg
14 Leonardo Sarto
13 Alex Dunbar
12 Sam Johnson
11 Rory Hughes
10 Finn Russell
9 Henry Pyrgos (Co-Captain)
1 Gordon Reid
2 Fraser Brown
3 Zander Fagerson
4 Tim Swinson
5 Jonny Gray (Co-Captain)
6 Robert Harley
7 Ryan Wilson
8 Josh Strauss
Substitutes
16 Pat MacArthur
17 Alex Allan
18 Sila Puafisi
19 Matt Fagerson
20 Lewis Wynne
21 Ali Price
22 Mark Bennett
23 Sean Lamont