Sean won 105 caps between 2004 and 2016, and is behind only Chris Paterson (109) and Ross Ford (107).
He returned to the Warriors - where he enjoyed a two-year spell earlier in his career - in 2012, and believes the time is right to retire.
Talking to BBC Scotland, Sean said: "Unless they beg me to stay another year, I think I'm done.
"I have had a great run and enjoyed every single moment but it is time to step aside. I am not going to flog a dead horse, although some might say I've been two years dead anyway!
"I love the sport, I love being in it and I love the guys I work with. But I just don't have the gas anymore. I can't get through those holes I see. I can still truck it up a distance, but there is definitely a blunting of the axe.
"It is disappointing it is coming to the end but I am 36 and I have done pretty well considering, when you look at the guys in the Scotland squad. Even if I was just arriving at my peak I don't think I would get in the current side."
Lamont started his career with English side Rotherham in 2000 before joining Glasgow, and also had spells with Northampton and Scarlets before returning to Scotland with the Warriors.
Sean has been restricted to just four starts in his 10 appearances this season.
"Lee Jones has been playing brilliantly, Rory Hughes has come through and re-signed for another two years," Sean noted. "It's time for me to move on and get a new line of work.
"I would love to stay in the sport, without a doubt. It has given me so much. The last few years I've enjoyed seeing the young guys come on more than playing myself.
"Working with Hoggy [Stuart Hogg], Rory Hughes, Mark Bennett... just helping out and passing on whatever wisdom I can. That has been a real enjoyment, so it is a good time to retire and coach."