The full-back will become the youngest Warriors player to reach the milestone, returning to the side at full-back for the 1872 Cup clash.
Zander Fagerson makes his 50th appearance at tight-head and become the youngest player to achieve that feat.
Captain Jonny Gray is joined by Scott Cummings in the second-row and Robert Harley, Chris Fusaro and Matt Fagerson pack down at the back of the scrum, the 18-year-old starting a game with his brother for the first time.
Glasgow Warriors head coach Gregor Townsend said: "We're really looking forward to the atmosphere which is going to be created at a sold-out Scotstoun tomorrow evening.
"It will be Gordon Reid, Sila Puafisi and Sean Lamont's last involvement with the club and we're looking to sending them off on a high. I'm sure all of the leavers will get a good reception from our supporters.
"It should be a cracking game as we're playing our fiercest rivals and there is a trophy at stake."
15 Stuart Hogg
Not available due to injury: Mark Bennett (knee), Simone Favaro (knee), Corey Flynn (head), James Malcom (ankle), D'arcy Rae (ankle), Leonardo Sarto (groin), Josh Strauss (medical), Richie Vernon (achilles) and Ryan Wilson (shoulder).