Rennie has named a much changed side following last weekend's victory over Benetton Rugby and Jonny Gray and Fraser Brown return to the starting XV having recovered from a wrist and an ankle injury respectively. Fraser Brown made his comeback from the bench last weekend.
Glasgow Warriors Head Coach Dave Rennie said: "It's great having Jonny (Gray) back. He's been working hard for a lot of weeks jumping out of his skin, so we're excited to have him in there.
"With Jonny and Fraser (Brown) back it gives us more experience on the field and they both bring a lot of physicality, which is going to be important against the Cheetahs.
"The Cheetahs can play a couple of different games. They have a big pack who can maul well and they have some real gas out wide, so they're prepared to play.
"We'll have to be accurate and really disciplined, but we want to play and hopefully the conditions will allow us to do that.
"Scott (Cummings) and Lee (Jones) have played all five games this season, plus the two trial matches we had before that, so it's a case of trying to freshen those guys up."
Unavailable players: Rory Hughes (shoulder), Chris Fusaro (head), Lelia Masaga (calf), James Malcolm (ankle), Alex Dunbar (knee), Stuart Hogg (shoulder), Oli Kebble (foot), Patrick Kelly (ankle), Ratu Tagive (achilles), Richie Vernon (achilles) and Samuela Vunisa (knee)