The Glasgow head coach has made a number of changes to the squad that went down to a last-minute defeat at Murrayfield last weekend.
Nick Grigg, Nikola Matawalu, Finn Russell, Kiran McDonald and Matt Fagerson come in, with the latter returning from injury having last played in the win against Leinster at the start of November.
Ruaridh Jackson continues at full-back, with Lee Jones and Nikola Matawalu on either wing. Nick Grigg and Alex Dunbar combine in midfield, while Finn Russell and Ali Price link-up at half-back.
The front-row remains unchanged with Jamie Bhatti, Fraser Brown and Zander Fagerson packing down. Kiran McDonald comes into the second-row and partners captain Jonny Gray in the engine room.
Matt Fagerson comes in to start at Number 8, with Robert Harley and Matt Smith continuing on either flank.
Lock Greg Peterson and scrum-half George Horne are named amongst the replacements, having been added to the match day 23.
Glasgow Warriors head coach Dave Rennie said: "It was a substandard performance last Saturday and we were hugely disappointed. We had so many opportunities to put them out of it and we didn't and they hurt us at the end.
"We know we have a lot of genuine support out there and we're disappointed we put in a performance like that over Christmas. We need to be better on Saturday and we certainly want to give the supporters a lot more to sing about than we did last week."
14 Lee Jones
13 Nick Grigg
12 Alex Dunbar
11 Nikola Matawalu
10 Finn Russell
9 Ali Price
1 Jamie Bhatti
2 Fraser Brown
3 Zander Fagerson
4 Kiran McDonald
5 Jonny Gray
6 Robert Harley
7 Matt Smith
8 Matt Fagerson
Substitutes
16 Pat MacArthur
17 Oli Kebble
18 Siua Halanukonuka
19 Greg Peterson
20 Chris Fusaro
21 George Horne
22 Peter Horne
23 Huw Jones
Not available due to injury: Brian Alainu'uese (knee), Adam Ashe (ankle), Callum Gibbins (achilles), Stuart Hogg (hip), Patrick Kelly (Achilles), Tommy Seymour (foot), Rory Hughes (shoulder), Sam Johnson (jaw), Lelia Masaga (knee), Leonardo Sarto (shoulder), Tim Swinson (hand), Ratu Tagive (achilles) and Ryan Wilson (ankle)