Nine Glasgow Warriors players have been selected in Gregor Townsend's squad
After making his comeback from injury against Exeter Chiefs earlier this month, Stuart Hogg starts at full-back. Scrum-half Ali Price start his ninth Test in the past ten Scotland matches to partner stand-off Finn Russell at half-back.
Tommy Seymour continues on the wing, while centre Huw Jones makes his first appearance for Scotland at inside-centre.
Jonny Gray is the only Warrior in the forwards, although Jamie Bhatti and Ryan Wilson are named amongst the replacements, with Wilson making his return from injury. Peter Horne is also named on the bench for the game in Cardiff.
Scotland
15 Stuart Hogg VICE CAPTAIN (Glasgow Warriors)
14 Tommy Seymour (Glasgow Warriors)
13 Chris Harris (Newcastle Falcons)
12 Huw Jones (Glasgow Warriors)
11 Byron McGuigan (Sale Sharks)
10 Finn Russell (Glasgow Warriors)
9 Ali Price (Glasgow Warriors)
1 Gordon Reid (London Irish)
2 Stuart McInally (Edinburgh Rugby)
3 Jon Welsh (Newcastle Falcons)
4 Ben Toolis (Edinburgh Rugby)
5 Jonny Gray VICE CAPTAIN (Glasgow Warriors)
6 John Barclay CAPTAIN (Scarlets)
7 Hamish Watson (Edinburgh Rugby)
8 Cornell du Preez (Edinburgh Rugby)
Substitutes
16 Scott Lawson (Newcastle Falcons)
17 Jamie Bhatti (Glasgow Warriors)
18 Murray McCallum (Edinburgh Rugby)
19 Grant Gilchrist (Edinburgh Rugby)
20 Ryan Wilson (Glasgow Warriors)
21 Greig Laidlaw (Clermont Auvergne)
22 Peter Horne (Glasgow Warriors)
23 Sean Maitland (Saracens)