It's almost a full Warriors back-line with full-back the only position not occupied by a Glasgow player.
The Horne brothers are the replacement half-back pairing, having both scored against Munster at Thomond Park last Saturday.
Taking place outside World Rugby's designated international window, the sides (made up wholly of home-based players) will contest the 'Doddie Weir Cup' as they honour the former Scotland and British & Irish Lions player diagnosed with Motor Neurone Disease and support his inspiring work to raise funds for MND research.
This week the Welsh Rugby Union and Scottish Rugby committed to donating a joint six-figure sum from the proceeds of the game, with the associated visibility for the fight against Motor Neurone Disease also providing an invaluable contribution.
Townsend said: "Doddie's a great man who's been inspirational in his fight against MND and it's fantastic that we're able to pay tribute to him and his achievements with this match.
"This Saturday the best way we, as a team, can pay tribute to him will be through our performance, delivering one in keeping with the occasion and that puts us in a position to make Doddie proud.
"There is an extra incentive that we are playing for a trophy in the shape of the Doddie Weir Cup."
15 Blair Kinghorn (Edinburgh)
1 Allan Dell (Edinburgh)
2 Stuart McInally CAPTAIN (Edinburgh)
3 Willem Nel (Edinburgh)
4 Ben Toolis (Edinburgh)
5 Jonny Gray (Glasgow Warriors)
6 Jamie Ritchie (Edinburgh)
7 Hamish Watson (Edinburgh)
8 Ryan Wilson VICE CAPTAIN (Glasgow Warriors)
16 Fraser Brown (Glasgow Warriors)
17 Alex Allan (Glasgow Warriors)
18 Simon Berghan (Edinburgh)
19 Grant Gilchrist (Edinburgh)
20 Matt Fagerson (Glasgow Warriors)
21 George Horne (Glasgow Warriors)
22 Peter Horne (Glasgow Warriors)
23 Darcy Graham (Edinburgh)