Adam Hastings starts at fly-half at home for the first time for his country with Finn Russell moving outside of him to centre.
Huw Jones set up one of the great all time tries against South Africa and retains his place in midfield and Stuart Hogg has recovered from a rolled ankle to start again at full-back.
In the pack Fraser Brown starts at Hooker and Jonny Gray packs down in the second-row.
Ryan Wilson drops to the bench having started every game so far this Autumn. Alex Allan is the other forward on the bench.
George Horne and Alex Dunbar also both come onto the bench
Scotland
15 Stuart Hogg VICE CAPTAIN (Glasgow Warriors)
14 Sean Maitland (Saracens)
13 Huw Jones (Glasgow Warriors)
12 Finn Russell (Racing 92)
11 Blair Kinghorn (Edinburgh)
10 Adam Hastings (Glasgow Warriors)
9 Greig Laidlaw CAPTAIN (Clermont Auvergne)
1 Allan Dell (Edinburgh)
2 Fraser Brown (Glasgow Warriors)
3 Simon Berghan (Edinburgh)
4 Grant Gilchrist (Edinburgh)
5 Jonny Gray VICE CAPTAIN (Glasgow Warriors)
6 Jamie Ritchie (Edinburgh)
7 Hamish Watson (Edinburgh)
8 Josh Strauss (Sale Sharks)
Substitutes
16 Stuart McInally (Edinburgh)
17 Alex Allan (Glasgow Warriors)
18 Willem Nel (Edinburgh)
19 Sam Skinner (Exeter Chiefs)
20 Ryan Wilson (Glasgow Warriors)
21 George Horne (Glasgow Warriors)
22 Alex Dunbar (Glasgow Warriors)
23 Byron McGuigan (Sale Sharks)