Nick Grigg will play his 50th game for Glasgow having made his Warriors debut in March 2016.
He is joined in midfield by Stafford McDowall, both players have been selected as McCrea Financial Services Warrior of the Month nominees by the coaching staff off the back of their performances in November.
George Horne returns to the starting XV and will have Brandon Thomson outside of him.
Nikola Matawalu has scored five tries in his last two games and starts again on the wing, Robbie Nairn is brought in to make his first start and home debut alongside Ruaridh Jackson in the back-three.
Alex Allan returns from Scotland camp to start at loose-head, with George Turner and D'arcy Rae completing the front-row.
Tim Swinson starts having returned from injury off the bench last week and Scott Cummings is his partner in the engine room.
Chris Fusaro will captain the side from the outset for the first time since January 2014, while Matt Smith and Adam Ashe are also named in the back-row.
On the bench Siua Halanukonuka returns from injury to feature for the first time this season and winger Ratu Tagive is also included for the first time this campaign.
Head Coach Dave Rennie said: "Winning is a habit and you want to keep doing that. Ultimately it is about performance, when I look back a few weeks ago we got beat by Munster but we played really well that night.
"We don't like losing. It is all about the quality of how we play and we know if we can perform with that intensity and accuracy, we are going to win more than we lose.
"We have been going pretty well recently and know we have more in us, I want to see more of that tomorrow night."
14 Robbie Nairn
13 Nick Grigg
12 Stafford McDowall
11 Nikola Matawalu
10 Brandon Thomson
9 George Horne
1 Alex Allan
2 George Turner
3 D'arcy Rae
4 Tim Swinson
5 Scott Cummings
6 Matt Smith
7 Chris Fusaro
8 Adam Ashe
Substitutes
16 Kevin Bryce
17 Oli Kebble
18 Siua Halanukonuka
19 Kiran McDonald
20 Tevita Tameilau
21 Nick Frisby
22 Patrick Kelly
23 Ratu Tagive
Players unavailable due to injury: Zander Fagerson (ankle), Rory Hughes (shoulder), Sam Johnson (knee), Lee Jones (knee) and Lelia Masaga (calf)