The capital side won the opening fixture 23-7 at BT Murrayfield and tomorrow's sold out game at Scotstoun is the second of three derby games this season with the teams facing off again in Glasgow in April.
He starts in midfield alongside Peter Horne who made his 150th appearance for the club in Edinburgh last weekend.
Glasgow Warriors Head Coach Dave Rennie said: "Defensively we played well last weekend but we didn't ask enough questions of Edinburgh in attack. We're going to have to be better in that department tomorrow.
"We're in a position where we can replace quality with quality. Five of the six players we're bringing in to the starting line-up are internationals, all six have played over 50 games for the club and four are centurions. We've named a very strong side.
"It's also a positive to welcome Sam (Johnson) back to the mix. He's battled a bit this season so we're looking forward to seeing him get back out there and do what he does best."
15 Stuart Hogg
Not available due to injury: Fraser Brown (knee), Zander Fagerson (ankle), Rory Hughes (shoulder), Huw Jones (chest), Lee Jones (knee), Lelia Masaga (calf), Kiran McDonald (calf) and George Turner (ankle).