Sam Johnson will make his international debut at inside centre, partnering Warriors teammate Huw Jones in midfield.
Stuart Hogg starts at full-back and is named Vice-Captain, Tommy Seymour joining him in the back three.
Ryan Wilson packs down at the back of the scrum, starting at number 8.
On the bench, Jamie Bhatti is loose-head prop cover and Ali Price and Adam Hastings will look to make in impact as replacement half-backs.
Scotland
15 Stuart Hogg (Glasgow Warriors)
14 Tommy Seymour (Glasgow Warriors)
13 Huw Jones (Glasgow Warriors)
12 Sam Johnson (Glasgow Warriors)
11 Blair Kinghorn (Edinburgh)
10 Finn Russell (Racing 92)
9 Greig Laidlaw CAPTAIN (Clermont Auvergne)
1 Allan Dell (Edinburgh)
2 Stuart McInally VICE-CAPTAIN (Edinburgh)
3 Willem Nel (Edinburgh)
4 Ben Toolis (Edinburgh)
5 Grant Gilchrist (Edinburgh)
6 Sam Skinner (Exeter Chiefs)
7 Jamie Ritchie (Edinburgh)
8 Ryan Wilson (Glasgow Warriors)
Substitutes
16 Jake Kerr (Leicester Tigers)
17 Jamie Bhatti (Glasgow Warriors)
18 Simon Berghan (Edinburgh)
19 Gary Graham (Newcastle Falcons)
20 Josh Strauss (Sale Sharks)
21 Ali Price (Glasgow Warriors)
22 Adam Hastings (Glasgow Warriors)
23 Chris Harris (Newcastle Falcons)
Squad players unavailable through injury: Jonny Gray (shoulder), George Horne (shoulder), Peter Horne (knee), Lee Jones (knee), Sean Maitland (hamstring), Grant Stewart (shoulder).