The 31-year-old made his Warriors debut in 2008 and re-joined the club in 2017 following a spell in the English Premiership.
He becomes the 12th player to reach the milestone. Ryan Wilson, Chris Fusaro and Peter Horne have also played their 150th games for Glasgow Warriors this season.
Robbie Nairn scored a brace of tries against Connacht last weekend and is rewarded with a place in the starting line-up this Saturday joining Jackson in the back three. Rory Hughes starts on the opposite wing.
Kyle Steyn shifts from wing to centre to partner Stafford McDowall. Adam Hastings returns from Scotland duty to start at fly-half with Nick Frisby inside of him.
Zander Fagerson also returns from international duty and starts alongside Oli Kebble and George Turner in the front-row.
Matt Fagerson is brought into the starting XV and he packs down with the experience of Robert Harley and Chris Fusaro either side of him.
In front of them, Tim Swinson and Scott Cummings continue their second-row partnership.
On the bench, Alex Allan makes it three players involved who also played for Scotland in Paris last Saturday.
Glasgow Warriors Head Coach Dave Rennie, said: "It's a great occasion for Jacko and his family. His contribution since re-joining can't be praised enough and he's a hugely popular member of the group. Hopefully we can get a result to mark the occasion for him.
"We were pleased to get the win against Connacht and did some things really well on the night. The challenge now is to improve on that and we're going to need to as trips to Italy are extremely challenging as we learned in January."
14 Robbie Nairn
13 Kyle Steyn
12 Stafford McDowall
11 Rory Hughes
10 Adam Hastings
9 Nick Frisby
1 Oli Kebble
2 George Turner
3 Zander Fagerson
4 Tim Swinson
5 Scott Cummings
6 Robert Harley
7 Chris Fusaro (Captain)
8 Matt Fagerson
Substitutes
16 Grant Stewart
17 Alex Allan
18 D'arcy Rae
19 Bruce Flockhart
20 Adam Ashe
21 Nikola Matawalu
22 Brandon Thomson
23 Patrick Kelly
Unavailable players: Suia Halanukonuka (head), George Horne (shoulder), Callum Gibbins (ankle/knee), Stuart Hogg (shoulder), Huw Jones (knee), Lee Jones (knee), Lelia Masaga (illness), Matt Smith (shoulder), DTH van der Merwe (shoulder), Ryan Wilson (knee)
Fraser Brown, Jonny Gray, Nick Grigg, Peter Horne, Sam Johnson, Ali Price, Tommy Seymour (all Scotland). Tevita Tameilau (USA)