The pair are two of seven Warriors selected by Gregor Townsend to face a Welsh team with aspirations of a Grand Slam.
Ali Price starts at scrum-half having come off the bench in Scotland's previous three games in this year's Six Nations.
Fraser Brown and Adam Hastings are named among the replacements, the fly-half is the only Glasgow player involved to have played for the Warriors in their 10-42 victory over Zebre in Parma last Saturday.
15 Blair Kinghorn (Edinburgh)
1 Allan Dell (Edinburgh)
2 Stuart McInally CAPTAIN (Edinburgh)
3 Willem Nel (Edinburgh)
4 Grant Gilchrist VICE CAPTAIN (Edinburgh)
5 Jonny Gray (Glasgow Warriors)
6 Magnus Bradbury (Edinburgh)
7 Jamie Ritchie (Edinburgh)
8 Josh Strauss (Sale Sharks)
16 Fraser Brown (Glasgow Warriors)
17 Gordon Reid (London Irish)
18 Simon Berghan (Edinburgh)
19 Ben Toolis (Edinburgh)
20 Hamish Watson (Edinburgh)
21 Greig Laidlaw (Clermont Auvergne)
22 Adam Hastings (Glasgow Warriors)
23 Byron McGuigan (Sale Sharks)