The pair are two of seven Warriors selected by Gregor Townsend to face a Welsh team with aspirations of a Grand Slam.
Ali Price starts at scrum-half having come off the bench in Scotland's previous three games in this year's Six Nations.
Peter Horne also comes into the starting XV and partners Warriors teammate Nick Grigg in midfield.
Fraser Brown and Adam Hastings are named among the replacements, the fly-half is the only Glasgow player involved to have played for the Warriors in their 10-42 victory over Zebre in Parma last Saturday.
Scotland
15 Blair Kinghorn (Edinburgh)
14 Tommy Seymour (Glasgow Warriors)
13 Nick Grigg (Glasgow Warriors)
12 Peter Horne (Glasgow Warriors)
11 Darcy Graham (Edinburgh)
10 Finn Russell VICE CAPTAIN (Racing 92)
9 Ali Price (Glasgow Warriors)
1 Allan Dell (Edinburgh)
2 Stuart McInally CAPTAIN (Edinburgh)
3 Willem Nel (Edinburgh)
4 Grant Gilchrist VICE CAPTAIN (Edinburgh)
5 Jonny Gray (Glasgow Warriors)
6 Magnus Bradbury (Edinburgh)
7 Jamie Ritchie (Edinburgh)
8 Josh Strauss (Sale Sharks)
Substitutes
16 Fraser Brown (Glasgow Warriors)
17 Gordon Reid (London Irish)
18 Simon Berghan (Edinburgh)
19 Ben Toolis (Edinburgh)
20 Hamish Watson (Edinburgh)
21 Greig Laidlaw (Clermont Auvergne)
22 Adam Hastings (Glasgow Warriors)
23 Byron McGuigan (Sale Sharks)