The Scots travel south in defence of the Calcutta Cup trophy they lifted for the first time in ten years at Murrayfield last year, with a victory in London escaping the Scots since 1983.
Sam Johnson comes into the side to partner Nick Grigg at centre, while Ali Price keeps his place at scrum-half.
Fraser Brown, Jonny Gray and Adam Hastings have been named on the bench.
Scotland
15 Sean Maitland (Saracens)
14 Darcy Graham (Edinburgh)
13 Nick Grigg (Glasgow Warriors)
12 Sam Johnson (Glasgow Warriors)
11 Byron McGuigan (Sale Sharks)
10 Finn Russell VICE CAPTAIN (Racing 92)
9 Ali Price (Glasgow Warriors)
1 Allan Dell (Edinburgh)
2 Stuart McInally CAPTAIN (Edinburgh)
3 Willem Nel (Edinburgh)
4 Ben Toolis (Edinburgh)
5 Grant Gilchrist VICE CAPTAIN (Edinburgh)
6 Sam Skinner (Exeter Chiefs)
7 Hamish Watson (Edinburgh)
8 Magnus Bradbury (Edinburgh)
Substitutes
16 Fraser Brown (Glasgow Warriors)
17 Gordon Reid (London Irish)
18 Simon Berghan (Edinburgh)
19 Jonny Gray (Glasgow Warriors)
20 Josh Strauss (Sale Sharks)
21 Greig Laidlaw (Clermont Auvergne)
22 Adam Hastings (Glasgow Warriors)
23 Chris Harris (Newcastle Falcons)