Gibbins picked up an injury in Glasgow's Heineken Champions Cup victory over Cardiff Blues in January and returns to the starting line-up as the Warriors gear up for the business end of the season.
Adam Hastings is named on the bench, the 22-year-old also came on as a replacement at Twickenham on Super Saturday.
Glasgow Warriors Head Coach Dave Rennie said: "We're rapt with the results we've picked up over the Six Nations.
"We got 19 points out of a possible 20, which is the best record across the PRO14 and are really pleased with the depth we're starting to build throughout the squad.
"A lot is made of Cheetahs' ability in attack and we know how lethal they are off turnover pill, so our handling accuracy is going to have to be paramount, but they've got lots of other strings to their bow.
"They have a massive, athletic pack so our physicality is going to have to be at its best to deal with that aspect of their game too."
16 Grant Stewart
17 Jamie Bhatti
18 Siua Halanukonuka
19 Bruce Flockhart
20 Chris Fusaro
21 Adam Hastings
22 Patrick Kelly
23 Robbie Nairn
Not available due to injury: Kevin Bryce (knee), Nick Grigg (ankle), Stuart Hogg (shoulder), George Horne (shoulder), Huw Jones (knee), Lee Jones (knee), Lelia Masaga (back), Kiran McDonald (back), Matt Smith (shoulder), George Turner (head), DTH van der Merwe (shoulder) and Ryan Wilson (knee)