The 26-year-old plays for the first time since injuring his shoulder in Scotland's Six Nations game against Ireland.
It is an unchanged pack from last Saturday's game at Scotstoun.
Meanwhile, following consultation with a specialist, George Turner has been stepped down from playing duties for the remainder of the season having sustained consecutive concussions.
The Hooker will continue to work with the club's medical team and strength and conditioning coaches to prepare himself for a return to action.
In other injury news, Nick Grigg has successfully undergone surgery at BMI Ross Hall on an ankle injury sustained playing for the national side. The centre is expected to be out of action for up to eight weeks.
Glasgow Warriors Head Coach Dave Rennie said: "It's a massive weekend and exactly the kind of game we want to be competing in.
"We know Saracens well having played them twice already this season. We tested them for big chunks of those games and know that if we play at our best for 80 minutes we have the firepower to make it to the semi-finals."
15 Stuart Hogg
Unavailable players: Bruce Flockhart (back), Nick Grigg (ankle), Huw Jones (knee), Lee Jones (knee) Kiran McDonald (back), D'arcy Rae (ankle), Tommy Seymour (ribs), Matt Smith (shoulder), George Turner (head), DTH van der Merwe (shoulder) and Ryan Wilson (knee)