The 25-year-old made his debut back in December 2012 in a PRO12 victory over Edinburgh before signing his first professional contract the following summer.
He made his Scotland debut in November 2013 and has since gone on to surpass 50 test matches for his country.
The former club captain was instrumental in Glasgow's 2014/15 PRO12 title-winning campaign and will be hoping to help his side take one step towards their first final since then, by marking his century with victory tomorrow night.
USA international Tevita Tameilau is included amongst the replacements for the first time since scoring against Cardiff Blues in February and representing his country four times in the Americas Rugby Championship.
Glasgow Warriors Head Coach Dave Rennie said: "It'll be a great occasion for Jonny and his family. To have played 100 games for your club and 50 for your country by the age of 25 is unheard of and a testament to Jonny and his work ethic.
"Historically these games have been tasty and it's great that we're going to have a packed, noisy stadium at our backs to carry us through. Everyone knows what's at stake.
"It's the business end of the season now and we've got ourselves in a pretty decent spot but the real fight starts now and the boys are certainly up for it."
15 Stuart Hogg
Unavailable players: Callum Gibbins (head), Nick Grigg (ankle), Huw Jones (knee), Lee Jones (knee), D'arcy Rae (ankle), Matt Smith (shoulder), Tim Swinson (ankle), George Turner (head), DTH van der Merwe (shoulder) and Ryan Wilson (knee)