Ulster come calling to Scotstoun on Friday and Hastings believes all three of the final regular-season games need to be won to secure that all-important home semi-final.
Munster are just three points behind and have a more straightforward run-in than the Warriors, who face a trip to Leinster then the visit of Edinburgh.
Last season, Glasgow ran away with top spot Conference A, but then paid for a three-week lay-off as they went down at home to Scarlets in the last four.
Looking ahead to the Ulster clash, Hastings told The Sottsman: "It's a huge game, back at home. If we're being realistic about this competition we want to finish top of our Conference, we need to win our last three games in the regular season, so this game's huge. Five points on Friday would be massive."
Hastings went on to say "strong words" had been exchanged after the 56-27 loss to Saracens, which Hastings freely admitted was "an absolute hammering".
"Being a fly-half you kind of have a big impact on the game and the decisions you make can affect a lot of the team performance, so I kind of have to speak as well," said Hastings.
"We spoke about it – we've got to go through the game, which is painful at the best of times. It's not easy, but you've got to go and watch all the stuff and learn from it, which we did on Monday morning.
"Take a lesson from it but, ultimately, we've got to put it behind us now. We've got three massive games coming up to finish off our regular season, so we'll look forward to that now."