Glasgow know that a win against the capital side will guarantee them top spot in Conference A and a home semi-final in the PRO14 Final Series.
Tom Gordon replaces Fusaro in the back-row, the 22-year-old making his first home start for the club. He started the PRO14 win against Cardiff Blues at the Arms Park in February and this will be his fourth appearance in a Warriors shirt, fresh from signing a new two-year deal this week.
On the bench, club co-captain Ryan Wilson is selected for the first time since getting injured playing for Scotland back in February.
Since injuring his hamstring in the opening minutes at the RDS, Chris Fusaro has now successfully undergone surgery and will not feature for the club again this season. Tim Swinson has undergone ankle surgery and will also be unavailable for the remaining games of this campaign.
"To win titles you have to be able to perform under pressure and we've shown in recent weeks, especially in the last two rounds against Ulster here and Leinster in Dublin, that we can rise to those occasions and actually thrive when there is a lot at stake.
"We've got ourselves in a good spot and we know if we win tomorrow night we won't have to leave Glasgow again this season."
15 Stuart Hogg
Unavailable players: Adam Ashe (head), Bruce Flockhart (shoulder), Chris Fusaro (hamstring), Callum Gibbins (head), Nick Grigg (ankle), Siua Halanukonuka (shoulder), Lee Jones (knee), Oli Kebble (back), Tim Swinson (ankle) George Turner (head) and DTH van der Merwe (shoulder)