The match will be the first of four Test matches for the national team in the coming weeks - Scotland host France in the return fixture next Saturday at BT Murrayfield, before away and home Tests against Georgia - all of which are designed to refine the selection decisions of Head Coach Gregor Townsend, who will name his final squad for Rugby World Cup 2019 next month.
Townsend said: "A huge amount of work has gone in throughout the past two months in order to deliver our best level of performance in the Rugby World Cup.
"These four Tests are a vital part of that process in terms of testing our systems and combinations but also in seeing which players put their best foot forward when it comes to selection for the final 31-man group going to Japan next month."
Glasgow Warriors stand-off Adam Hastings is handed his first start since the 2018 Autumn Test victory over Argentina, alongside clubmate and scrum-half Ali Price, while a new-look centre partnership of Duncan Taylor (Saracens) and Huw Jones (Glasgow Warriors) mans the midfield for the first time.
There are notable inclusions in the match day squad for Glasgow Warriors lock Scott Cummings and Northampton Saints midfielder Rory Hutchinson, who will make their Test debut if called upon from the bench in Nice this Saturday.
Townsend added: "As a coaching group we're pleased to be able to take a strong squad across to France for this opening Test.
"We've enjoyed seeing the players working hard and becoming closer as a team in our camp.
"We've been impressed by the quality of play they've delivered in training but fundamentally it'sbeen about preparing to play.
"We're now very much looking forward to seeing our men perform in these Test matches."
15 Stuart Hogg VICE CAPTAIN (Exeter Chiefs)
1 Jamie Bhatti (Edinburgh)
2 Stuart McInally CAPTAIN (Edinburgh)
3 Simon Berghan (Edinburgh)
4 Ben Toolis (Edinburgh)
5 Grant Gilchrist (Edinburgh)
6 John Barclay VICE CAPTAIN (Edinburgh)
7 Jamie Ritchie (Edinburgh)
8 Josh Strauss (Blue Bulls)
16 George Turner (Glasgow Warriors)
17 Gordon Reid (Ayrshire Bulls)
18 Zander Fagerson (Glasgow Warriors)
19 Scott Cummings (Glasgow Warriors)
20 Matt Fagerson (Glasgow Warriors)
21 George Horne (Glasgow Warriors)
22 Rory Hutchinson (Northampton Saints)
23 Blair Kinghorn (Edinburgh)