Wilson returns to the starting lineup having missed last weekend's victory in Tbilisi.
Jonny Gray makes his first appearance of the summer in the second-row, having shaken off a hamstring strain sustained earlier in pre-season.
He will partner club-mate Scott Cummings in the engine room, the same second-row pairing that started in the PRO14 Final at Celtic Park back in May.
Sam Johnson starts for the second successive Test at inside-centre, having made an impressive return to action in Georgia last weekend.
Tommy Seymour completes the Glasgow contingent in the starting XV, following the winger's successful completion of the return-to-play protocols after sustaining a concussion against France a fortnight ago.
Three more Warriors will be waiting in the wings for their chance to impress, with Grant Stewart joined by the Horne brothers on Scotland's bench.
15 Blair Kinghorn (Edinburgh)
1 Gordon Reid (Ayrshire Bulls)
2 George Turner (Glasgow Warriors)
3 Zander Fagerson (Glasgow Warriors)
4 Scott Cummings (Glasgow Warriors)
5 Jonny Gray VICE CAPTAIN (Glasgow Warriors)
6 Ryan Wilson CAPTAIN (Glasgow Warriors)
7 Jamie Ritchie (Edinburgh)
8 Blade Thomson (Scarlets)
16 Grant Stewart (Glasgow Warriors)
17 Allan Dell (Edinburgh)
18 Simon Berghan (Edinburgh)
19 Ben Toolis (Edinburgh)
20 Magnus Bradbury (Edinburgh)
21 George Horne (Glasgow Warriors)
22 Peter Horne (Glasgow Warriors)
23 Chris Harris (Gloucester)