A 30-man squad has been selected, including 12 players who did not feature in Belfast last weekend.
Andrew Davidson comes into the second row alongside last week's captain Tim Swinson, with Robert Harley and Chris Fusaro bringing a combined total of 376 Warriors appearances to a back row completed by Adam Ashe at Number Eight. Fusaro will captain the side this weekend.
Last season's Land Rover Young Player of the Season Stafford McDowall starts alongside Huw Jones in midfield, in what will be Jones' first Glasgow Warriors appearance since returning from the Scotland set-up.
Bruce Flockhart joins fellow former Highland RFC product Patrick Kelly on the bench, with Jamie Dobie making it a trio of Inverness natives in the Warriors squad. Dobie, 18, is in line to make his first appearance at Scotstoun.
Ruaridh Jackson, Callum Gibbins, Sean Kennedy and Alex Allan provide an experienced edge to the bench, with Adam Nicol, Kiran McDonald, Tom Gordon, Nick Grigg and Ratu Tagive - all starters at the Kingspan Stadium - rounding off the replacements.
Meanwhile, it has been confirmed that back-rower Jale Vakaloloma is set for a spell on the sidelines, having successfully undergone shoulder surgery at BMI Ross Hall Hospital.
The Fijian, who arrived at Scotstoun this summer from Brisbane City in Australia's National Rugby Championship, will be out for up to four months following the procedure.
Speaking ahead of the match, Dave Rennie said: "We've been working hard on our defensive structures, our line-speed and so on, but we know we have to be better all around the park this weekend.
"We had a lot of new players and combinations out there who will be better for the experience.
"Scotstoun is a fantastic place to play rugby. The crowd is really engaged with the game and are always incredibly vocal - the boys love playing here."
15 Glenn Bryce
Grant Stewart, Alex Allan, Adam Nicol, Kiran McDonald, Bruce Flockhart, Sean Kennedy, Patrick Kelly, Ruaridh Jackson, Charlie Capps, Callum Gibbins, Matt Fagerson, Jamie Dobie, Nick Grigg, Ratu Tagive, Gavin Lowe