An all-Glasgow midfield combination will line up in the blue of Scotland on Saturday evening, as Huw Jones returns to the international setup to partner club-mate Sam Johnson.
Adam Hastings makes his first Six Nations start at fly-half, with Ali Price following up the news of his new contract with the Warriors by earning the nod at scrum-half.
Zander Fagerson is rewarded for his fine form this season with the starting berth at tight-head prop, joining vice-captain Fraser Brown in the Scotland front-row.
Gregor Townsend has also selected a familiar Warriors pairing in the second-row, as Scott Cummings continues his run of being part of every matchday 23 since his debut last summer by partnering Jonny Gray in the engine room.
The Glasgow contingent is completed by George Horne, the former Howe of Fife man in line to make his first championship appearance from the replacements bench.
Kick-off for Scotland's opening match of the 2020 Guinness Six Nations is at 4.45pm on Saturday evening, with the match live on STV and ITV.
Scotland
15 Stuart Hogg CAPTAIN (Exeter Chiefs)
14 Sean Maitland (Saracens)
13 Huw Jones (Glasgow Warriors)
12 Sam Johnson (Glasgow Warriors)
11 Blair Kinghorn (Edinburgh)
10 Adam Hastings (Glasgow Warriors)
9 Ali Price (Glasgow Warriors)
1 Rory Sutherland (Edinburgh)
2 Fraser Brown VICE CAPTAIN (Glasgow Warriors)
3 Zander Fagerson (Glasgow Warriors)
4 Scott Cummings (Glasgow Warriors)
5 Jonny Gray (Glasgow Warriors)
6 Jamie Ritchie (Edinburgh)
7 Hamish Watson (Edinburgh)
8 Nick Haining (Edinburgh)
Substitutes:
16 Stuart McInally (Edinburgh)
17 Allan Dell (London Irish)
18 Simon Berghan (Edinburgh)
19 Ben Toolis (Edinburgh)
20 Cornell du Preez (Worcester Warriors)
21 George Horne (Glasgow Warriors)
22 Rory Hutchinson (Northampton Saints)
23 Chris Harris (Gloucester)