Gregor Townsend has also selected a familiar Warriors pairing in the second-row, as Scott Cummings continues his run of being part of every matchday 23 since his debut last summer by partnering Jonny Gray in the engine room.
The Glasgow contingent is completed by George Horne, the former Howe of Fife man in line to make his first championship appearance from the replacements bench.
Kick-off for Scotland's opening match of the 2020 Guinness Six Nations is at 4.45pm on Saturday evening, with the match live on STV and ITV.
15 Stuart Hogg CAPTAIN (Exeter Chiefs)
1 Rory Sutherland (Edinburgh)
2 Fraser Brown VICE CAPTAIN (Glasgow Warriors)
3 Zander Fagerson (Glasgow Warriors)
4 Scott Cummings (Glasgow Warriors)
5 Jonny Gray (Glasgow Warriors)
6 Jamie Ritchie (Edinburgh)
7 Hamish Watson (Edinburgh)
8 Nick Haining (Edinburgh)
16 Stuart McInally (Edinburgh)
17 Allan Dell (London Irish)
18 Simon Berghan (Edinburgh)
19 Ben Toolis (Edinburgh)
20 Cornell du Preez (Worcester Warriors)
21 George Horne (Glasgow Warriors)
22 Rory Hutchinson (Northampton Saints)
23 Chris Harris (Gloucester)