Jamie Dobie will make his first start in a Glasgow Warriors jersey. The 18-year-old - who is in his first season as a professional - has made six appearances from the bench so far in 2019/20, having become the first player born in the 21st century to represent the club in the Guinness PRO14.
Dobie's inclusion in the starting XV is one of six personnel changes made by head coach Dave Rennie, as his side looks to continue its undefeated run in 2020.
Grant Stewart returns to the matchday squad for the first time since last month's away win over Benetton, with the former Dalziel hooker packing down between Aki Seiuli and Oli Kebble in the front-row.
There's a potential debutant amongst the replacements for the second week running, with tight-head Ewan McQuillan in line to make his first appearance since joining on a short-term deal from FOSROC Super6 side Southern Knights.
A two-try showing from the bench last time out sees Mesu Dolokoto retain the number 16 shirt, whilst Andrew Davidson makes a return to the matchday squad since a try-scoring cameo of his own in Treviso last month.
Speaking to glasgowwarriors.org following his selection, Rennie said: "We've prepared well for this weekend. We know that it's the stage in the season where internationals take precedence, but we've got great depth and it's a chance for our boys to step up.
"I thought Jamie (Dobie) was really good off the bench last week. It's a great opportunity for him - we think he's got a big future and it's a chance for him to show that from the start this time out.
"We want to build on the Zebre result - we scored eight tries last week, but we went to sleep for parts of that game. We want to gain control and build some pressure, as well as play with more intensity. We've trained with real intensity this week and we're keen to show that tomorrow night."
15 Glenn Bryce
Not available due to injury: Adam Ashe (calf), Bruce Flockhart (back), Jonny Gray (hand), Siua Halanukonuka (calf), Kiran McDonald (hip), Stafford McDowall (Calf), Robbie Nairn (knee), D'arcy Rae (hand), Adam Nicol (calf), Jale Vakaloloma (shoulder), DTH van der Merwe (foot)