Four Warriors are in the starting XV as Scotland go in search of a first win in the Welsh capital since 2002.
After his performance against France earned a nomination for the Guinness Six Nations Player of the Round, Adam Hastings will once again look to control the side from fly-half.
Up front, Zander Fagerson is the sole Glasgow representative in the starting pack as the tight-head continues his run of consecutive starts in the Guinness Six Nations.
Five further Warriors are included on the bench, with Kyle Steyn retained in the matchday 23 following his debut appearance for Scotland last weekend.
There's also a recall to the matchday 23 for Matt Fagerson, with the back-rower in line for what would be his seventh cap in the famous dark blue jersey.
George Horne completes the Glasgow contingent, as Townsend's men look to complete this year's tournament with a third consecutive victory.
Kick off for Saturday's match is at 2.15pm, with the match live on BBC and BBC Radio Scotland.
15 Stuart Hogg CAPTAIN (Exeter Chiefs)
1 Rory Sutherland (Edinburgh)
2 Stuart McInally VICE CAPTAIN (Edinburgh)
3 Zander Fagerson (Glasgow Warriors)
4 Sam Skinner (Exeter Chiefs)
5 Grant Gilchrist (Edinburgh)
6 Jamie Ritchie (Edinburgh)
7 Hamish Watson (Edinburgh)
8 Magnus Bradbury (Edinburgh)
16 Fraser Brown (Glasgow Warriors)
17 Allan Dell (London Irish)
18 Willem Nel (Edinburgh)
19 Scott Cummings (Glasgow Warriors)
20 Matt Fagerson (Glasgow Warriors)
21 George Horne (Glasgow Warriors)
22 Duncan Weir (Worcester Warriors))
23 Kyle Steyn (Glasgow Warriors)