Fraser Brown will lead the side out on Saturday evening after being named as one of the squad's co-captains earlier this week, a year after skippering the Warriors to a 34-10 victory over Edinburgh at Scotstoun.
Oli Kebble and Zander Fagerson will pack down on either side of Brown in the front row while an all-Scotland pairing of Scott Cummings and Richie Gray forms a formidable second-row partnership, the latter in line to make his first Glasgow Warriors appearance since 2012 after re-joining the club earlier this summer.
A try-scorer in Glasgow's last fixture at BT Murrayfield, Huw Jones starts at full-back for the first time since joining the club in 2017, as Tommy Seymour and Ratu Tagive are selected to start on the wings.
George Turner and D'arcy Rae join Evans as the front-row replacements, whilst Kiran McDonald and Tom Gordon - winner of the club' Most Improved Player of the Season award for 2019/20 - complete the cover for the pack.
The replacements are rounded out by Glenn Bryce, as the Alloa man caps off a week that saw him agree to a contract extension until the end of 2020 by claiming the 23 jersey.
Speaking to glasgowwarriors.org, Wilson said: "This is the first opportunity for myself and the coaching team to look at different combinations, and we'be considered a number of factors when selecting this side.
"We'be looked closely on how we bring our own style into the game, as well as the weapons we know that Edinburgh will bring tomorrow evening.
"We've had to consider our options at 15, and Huw is someone that we felt can be a real asset in that position. His running ability is second to none, and he'll bring a lot of attacking strength.
"We're also grateful to Scarlets for loaning us Dylan (Evans) as cover in a position where we'be currently got a couple of injuries - he's an athletic loose-head and he's capable of making an impression off the bench.
"The boys have trained well this week and they're all looking forward to getting back out and into a competitive match."
15 Huw Jones