Fraser Brown will lead the side out on Saturday evening after being named as one of the squad's co-captains earlier this week, a year after skippering the Warriors to a 34-10 victory over Edinburgh at Scotstoun.
Oli Kebble and Zander Fagerson will pack down on either side of Brown in the front row while an all-Scotland pairing of Scott Cummings and Richie Gray forms a formidable second-row partnership, the latter in line to make his first Glasgow Warriors appearance since 2012 after re-joining the club earlier this summer.
Matt Fagerson starts at openside flanker for the first time this season, with vastly-experienced duo RobZerg Harley and Ryan Wilson completing the back-row.
The backline sees Ali Price get the nod at scrum-half, as Adam Hastings lines up outside him in the number 10 jersey.
Peter Horne and Nick Grigg are paired together in the centres, with both men retaining their places in the starting XV from the club's last outing back in February.
A try-scorer in Glasgow's last fixture at BT Murrayfield, Huw Jones starts at full-back for the first time since joining the club in 2017, as Tommy Seymour and Ratu Tagive are selected to start on the wings.
On the bench, Dylan Evans is in line to become the 311th player to represent the club after arriving on a short-term loan deal from the Scarlets to provide cover at loose-head prop.
George Turner and D'arcy Rae join Evans as the front-row replacements, whilst Kiran McDonald and Tom Gordon - winner of the club' Most Improved Player of the Season award for 2019/20 - complete the cover for the pack.
George Horne and Nikola Matawalu will be looking to make an impact from the bench if and when called upon tomorrow evening, with the pair boasting 73 tries between them in Glasgow colours.
The replacements are rounded out by Glenn Bryce, as the Alloa man caps off a week that saw him agree to a contract extension until the end of 2020 by claiming the 23 jersey.
Speaking to glasgowwarriors.org, Wilson said: "This is the first opportunity for myself and the coaching team to look at different combinations, and we'be considered a number of factors when selecting this side.
"We'be looked closely on how we bring our own style into the game, as well as the weapons we know that Edinburgh will bring tomorrow evening.
"We've had to consider our options at 15, and Huw is someone that we felt can be a real asset in that position. His running ability is second to none, and he'll bring a lot of attacking strength.
"We're also grateful to Scarlets for loaning us Dylan (Evans) as cover in a position where we'be currently got a couple of injuries - he's an athletic loose-head and he's capable of making an impression off the bench.
"The boys have trained well this week and they're all looking forward to getting back out and into a competitive match."
15 Huw Jones
14 Tommy Seymour
13 Nick Grigg
12 Peter Horne
11 Ratu Tagive
10 Adam Hastings
9 Ali Price
1 Oli Kebble
2 Fraser Brown (Captain)
3 Zander Fagerson
4 Richie Gray
5 Scott Cummings
6 Robert Harley
7 Matt Fagerson
8 Ryan Wilson
Substitutes
16 George Turner
17 Dylan Evans
18 D'arcy Rae
19 Kiran McDonald
20 Tom Gordon
21 George Horne
22 Nikola Matawalu
23 Glenn Bryce
Unavailable for selection: Alex Allan, Adam Ashe, Hamish Bain, Mesu Dolokoto, Sam Johnson, Lee Jones, Leone Nakarawa, Adam Nicol, Aki Seiuli, Kyle Steyn, Brandon Thomson, George Thornton