The 31-year-old is one of nine Glasgow Warriors selected in the matchday 23, whilst his tally of 50 caps is more than any other player selected by Townsend for Scotland's first match in over seven months.
Brown is joined in the front-row by club-mate Zander Fagerson, with Scott Cummings continuing his remarkable run of international involvement by being named in a Scotland matchday squad for the 13th fixture in succession.
Matt Fagerson is selected at number eight, as the back-rower makes his first start for Scotland since last August's win over Georgia in Tbilisi.
Oli Kebble is in line to make his international debut from the bench, after the loose-head prop's performances at the start of the 2020/21 season earned him a first Scotland call-up.
Also amongst the replacements is Robert Harley, who could make his first Scotland appearance since February 2019 on Friday night.
George Horne rounds out the Glasgow cohort, as the scrum-half continues his run of being named in every Scotland matchday 23 in 2020.
15 Blair Kinghorn (Edinburgh)
14 Darcy Graham (Edinburgh)
13 Chris Harris (Gloucester)
12 James Lang (Harlequins)
11 Duhan van der Merwe (Edinburgh)
1 Rory Sutherland (Edinburgh)
2 Fraser Brown CAPTAIN (Glasgow Warriors)
3 Zander Fagerson (Glasgow Warriors)
4 Ben Toolis (Edinburgh)
5 Scott Cummings (Glasgow Warriors)
6 Jamie Ritchie VICE CAPTAIN (Edinburgh)
7 Hamish Watson (Edinburgh)
8 Matt Fagerson (Glasgow Warriors)
16 Stuart McInally (Edinburgh)
17 Oli Kebble (Glasgow Warriors)
18 Simon Berghan (Edinburgh)
19 Robert Harley (Glasgow Warriors)
20 Nick Haining (Edinburgh)
21 Cornell du Preez (Worcester Warriors)
22 George Horne (Glasgow Warriors)
23 Finn Russell (Racing 92)