There are nine changes in total to the side that claimed a 20-7 victory over Scarlets last time out, with Wilson still able to select a matchday 23 containing 16 internationals for the visit to Swansea.
Sean Kennedy is in line to make his first competitive appearance for Glasgow Warriors in over seven years should he come off the bench tomorrow evening, the scrum-half's previous outing for the club having come in February 2013 during a short-term loan spell.
There could also be first appearances of the season for Alex Allan, Grant Stewart and Brandon Thomson, the latter having scored all of Glasgow's points in their most recent meeting with the Ospreys at Scotstoun in 2019.
Argentina prop Enrique Pieretto and Tongan back-rower Fotu Lokotui are both included in the 23 for the second away fixture in succession, having both been included in the squad that took on Connacht in Galway three weeks ago.
The bench is completed by Nikola Matawalu, who has fond memories of his most recent trip to the Liberty Stadium; the Fijian crossed for a hat-trick in November 2018 en route to helping his team claim a bonus-point victory.
"The team includes some new combinations that we are looking forward to seeing in action.
"It's good to welcome back a couple of the boys who have been released to us from Scotland camp.
"TJ [Ioane] and Hamish [Bain] will be making their debut for the club, and it will be the first time I get to see Sam [Johnson] and Jamie [Dobie] in a Warriors shirt.
"Ospreys have started off the season well. They have a good mix of young talent and experienced veterans in their squad - similar to us.
"We've prepared well and are up for the challenge we'll face tomorrow in Swansea."
15 Huw Jones