The new tournament sees Scotland open their campaign against Italy on Saturday lunchtime, before facing Fiji and France at BT Murrayfield over the coming fortnight.
Sam Johnson is at inside centre, making his first Scotland appearance since March.
Ali Price is at scrum-half, having played the full 80 minutes in last month's victory over Wales in Llanelli.
Up front, Zander Fagerson continues at tight-head for his third consecutive start in the Scotland front-row, while Scott Cummings' run of Test matches will be extended once again this weekend, as the second-rower makes it 15 successive appearances for his country since his debut in August 2019.
The bench once again sees the inclusion of Oli Kebble amongst the front row replacements, the Glasgow loose head having impressed in his appearances against Georgia and Wales.
George Turner completes the Warriors cohort in the matchday 23, with the hooker in line to make his first Scotland appearance since the 2019 Rugby World Cup win over Russia in Shizuoka.
15 Stuart Hogg (Exeter) CAPTAIN
1 Rory Sutherland (Edinburgh)
2 Stuart McInally (Edinburgh)
3 Zander Fagerson (Glasgow Warriors)
4 Scott Cummings (Glasgow Warriors)
5 Jonny Gray (Exeter)
6 Jamie Ritchie (Edinburgh)
7 Hamish Watson (Edinburgh)
8 Blade Thomson (Scarlets)
16 George Turner (Glasgow Warriors)
17 Oli Kebble (Glasgow Warriors)
18 WP Nel (Edinburgh)
19 Sam Skinner (Exeter)
20 Nick Haining (Edinburgh)
21 Sam Hidalgo-Clyne (Exeter)
22 James Lang (Harlequins)
23 Blair Kinghorn (Edinburgh)