Brown returns to the starting XV after missing out on last weekend's win over Italy, with the hooker also named as one of Scotland's vice-captains for the visit of France.
There's also a first Scotland start for Oli Kebble, as the Warriors loose-head is promoted to the number one jersey for his fourth cap.
Scott Cummings once again retains his place in the second-row, 15 months after lining up against France for his international debut.
Matt Fagerson is selected for the first time since being forced off with a knock against Georgia last month, as the number eight lines up to win his eighth cap for his country.
Ali Price makes his fourth start of the autumn at scrum-half, having also started against the French at BT Murrayfield in this year’s Guinness Six Nations.
He's joined in the back division by Sam Johnson, following the centre's return to the international setup in Florence last weekend.
Two further Warriors are included amongst the replacements, with both men having crossed the whitewash against the Italians in the Autumn Nations Cup opener.
15 Stuart Hogg CAPTAIN (Exeter Chiefs)
1 Oli Kebble (Glasgow Warriors)
2 Fraser Brown VICE CAPTAIN (Glasgow Warriors)
3 Simon Berghan (Edinburgh)
4 Scott Cummings (Glasgow Warriors)
5 Jonny Gray (Exeter Chiefs)
6 Jamie Ritchie VICE CAPTAIN (Edinburgh)
7 Hamish Watson (Edinburgh)
8 Matt Fagerson (Glasgow Warriors)
16 George Turner (Glasgow Warriors)
17 Jamie Bhatti (Edinburgh)
18 Zander Fagerson (Glasgow Warriors)
19 Sam Skinner (Exeter Chiefs)
20 Blade Thomson (Scarlets)
21 Sam Hidalgo-Clyne (Exeter Chiefs)
22 Duncan Taylor (Saracens)
23 Sean Maitland (Saracens)