It means that Scotland U20 star Rufus McLean will make his club debut on the wing this weekend, whilst Ross Thompson starts for the Warriors at fly-half for the first time after making his debut at BT Murrayfield a fortnight ago.
A mixture of youth and experience forms the half-back partnership, as Ali Price - the Glasgow back with the most appearances for the club - lines up alongside fly-half Thompson.
There are two further potential debutants named amongst the replacements for tomorrow evening's encounter, as academy duo Tom Lambert and Ollie Smith are named in a Glasgow matchday 23 for the first time.
Nakarawa is in line for his first Glasgow appearance in 11 months, with the Fijian's most recent Warriors outing coming in the club's last home match pre-COVID-19 against the Dragons back in February 2020.
Academy prospect and Scotland U20 flyer Smith will look to demonstrate his pace and footwork to the Warrior Nation should he come off the bench tomorrow evening, with Brandon Thomson completing the matchday 23.
Speaking to glasgowwarriors.org, Head Coach Wilson said: "Like we said last weekend, we want to give an opportunity to a few boys we think deserve their shot based on their efforts in training over the last couple of weeks.
"There are a lot of highlights in this week's team selection. We're excited to see how Ross (Thompson) goes at fly-half and for Rufus (McLean) to get his first run out for the club.
"On the bench we're looking forward to welcoming back Leone and giving Tom Lambert and Ollie Smith their first taste of senior rugby.
"We've worked hard this week in training, and we're excited to get the game underway."
15 Huw Jones
Unavailable for selection: Alex Allan, Fraser Brown, Adam Hastings, George Horne, Peter Horne, Sam Johnson, Oli Kebble, Paddy Kelly, Sean Kennedy, Nikola Matawalu, Kiran McDonald, Ewan McQuillin, Tommy Seymour, Kyle Steyn, George Thornton.