George Horne will make his long-awaited return from injury having been sidelined since December with a foot injury. He takes his place at scrum-half for Glasgow's final match of the shortened 2020/21 Guinness PRO14 campaign.
Kiran McDonald shifts to the blindside to accommodate the inclusion of Scott , as - with Ryan Wilson in line to win his 50th cap for Scotland this weekend after being called up earlier this week - an all-new back-row sees Fotu Lokotui promoted from the replacements to start at openside and TJ Ioane named at number eight.
Ross Thompson continues at fly-half for the fourth successive match, partnering Horne in the half-backs for the first time in his professional career.
Robbie Fergusson pulls on the Glasgow jersey for the final time before linking up with the Great Britain 7s squad to battle for a place at the Tokyo Olympics, as the Scotland 7s captain starts alongside Nick Grigg in midfield.
Fresh from agreeing a contract extension earlier this week Hamish Bain is named in the number 19 jersey, whilst Thomas Gordon rotates to the bench after starting every match to date in 2021.
Nikola Matawalu completes the bench, with the Fijian in line for his first Glasgow outing since December's clash with the Dragons at Scotstoun.
Speaking following selection, Head Coach Danny Wilson told glasgowwarriors.org: "As a coaching and playing group last week's performance was one we were all disappointed with and we need to bounce back with a good performance this weekend.
"With the likes of Ryan [Wilson], Rob [Harley], Rufus [McLean] and Jamie [Dobie] away with our Scotland internationals, others get the chance to step up and stake a claim for the jersey.
"It's great to welcome George [Horne] back - having the likes of him and Fraser [Brown] back available to us is a massive boost.
"Benetton will have their internationals back with them, and like us they will be looking to build some momentum ahead of next weekend's European fixtures."
15 Ollie Smith