Wilson has made five alterations to his starting lineup for what will be the first competitive fixture in front of fans at Scotstoun since February 2020.
A nine-try thriller in Belfast last time out ultimately went against the Warriors, despite taking a four-try bonus-point away from the Kingspan Stadium in addition to their tally for losing by less than seven points.
Sione Tuipulotu makes his competitive home debut at outside centre after impressing on his first start for the club last weekend, as the 24-year-old starts alongside Sam Johnson in the Glasgow midfield.
FOSROC Scottish Rugby Academy tight-head Murphy Walker is in line for his professional debut after being selected amongst the replacements, with the 21-year-old having impressed in FOSROC Super6 action for Stirling County in recent weeks.
Back-rower Ally Miller will also make his first appearance in Glasgow Warriors colours should he come off the bench tomorrow afternoon, after the former Scotland 7s star was selected for the first time since his summer move from Edinburgh.
Speaking following selection, Head Coach Wilson told glasgowwarriors.org: "We're looking forward to being back in front of a packed out Scotstoun tomorrow afternoon.
"There were a lot of positives to take and some things to work on from last weekend's game against Ulster we were really physical and played some high tempo rugby, scored some really good tries.
"Tomorrow a couple of boys get their first opportunity of the season to showcase what they're about. We're looking forward to seeing the likes Ally and Murphy take their opportunities when called upon
"Sharks are a big physical side with some serious gas on the wings. We're exciting by the challenge they pose and we'll need to match their physicality in both attack and defence to come away with a win."
15 Cole Forbes
Unavailable for selection: Simon Berghan, Sebastian Cancelliere, Rory Darge, Matt Fagerson, Zander Fagerson, Oli Kebble, Kiran McDonald, Ewan McQuillin, Domingo Miotti, Enrique Pieretto, Ali Price, Ratu Tagive, Duncan Weir