Six Glasgow Warriors are included in the matchday 23 for the encounter at BT Murrayfield.
Having been a standout performer in last year's win at Twickenham, George Turner will be looking to once again make an impact as he starts at hooker.
Zander Fagerson joins club-mate Turner in the front-row, making his seventh consecutive start in the dark blue jersey.
Matt Fagerson is selected at number eight, with only Hamish Watson having carried more times for Scotland during last year's tournament.
Ali Price continues at scrum-half, having started every match during the Autumn Nations Series in the number nine shirt.
Sam Johnson lines up at inside centre, the 28-year-old earning his 22nd cap in the midfield.
The Glasgow representation is completed by the inclusion of Sione Tuipulotu amongst the replacements, as the centre - who made his Scotland debut against Tonga in the Autumn Nations Series - looks to build upon last weekend's Player of the Match-winning performance in the 42-20 victory away to Connacht.
Scotland
15 Stuart Hogg - Exeter Chiefs - (Captain)
14 Darcy Graham - Edinburgh Rugby
13 Chris Harris - Gloucester Rugby
12 Sam Johnson - Glasgow Warriors
11 Duhan van der Merwe - Worcester Warriors
10 Finn Russell - Racing 92 - (Vice-Captain)
9 Ali Price - Glasgow Warriors
1 Rory Sutherland - Worcester Warriors
2 George Turner - Glasgow Warriors
3 Zander Fagerson - Glasgow Warriors
4 Jonny Gray - Exeter Chiefs
5 Grant Gilchrist - Edinburgh Rugby
6 Jamie Ritchie - Edinburgh Rugby - (Vice-Captain)
7 Hamish Watson - Edinburgh Rugby
8 Matt Fagerson - Glasgow Warriors
Substitutes
16 Stuart McInally - Edinburgh Rugby
17 Pierre Schoeman - Edinburgh Rugby
18 WP Nel - Edinburgh Rugby
19 Sam Skinner - Exeter Chiefs
20 Magnus Bradbury - Edinburgh Rugby
21 Ben White - London Irish
22 Blair Kinghorn - Edinburgh Rugby
23 Sione Tuipulotu - Glasgow Warriors