A total of 20 teams will compete for the title, comprised of eight teams from the United Rugby Championship, six from the French TOP14, five from the English Premiership, and South African outfit Toyota Cheetahs.
The clubs will be divided into two pools of 10, with the pool stages played out over four rounds of matches - two home and two away.
The live-streamed draw for the EPCR Challenge Cup pools is also scheduled to take place at the Aviva Stadium on Tuesday 28 June, with the clubs separated into three tiers based on their rankings, and clubs from the same league will not play against one another during the pool stage.
The six highest-ranked clubs from each pool, as well as the ninth and tenth ranked clubs from both of the Heineken Champions Cup pools, will qualify for a Round of 16, which will be followed by quarter-finals, semi-finals and the final at the Aviva Stadium on 19 May 2023.
2022/23 Challenge Cup dates:
Round One - 9/10/11 December 2022
Round Two - 16/17/18 December 2022
Round Three - 13/14/15 January 2023
Round Four - 20/21/22 January 2023
Round of 16 - 31 March/ 1/2 April 2023
Quarter-finals - 7/8/9 April 2023
Semi-finals - 28/29/30 April 2023
EPCR Challenge Cup final - Friday 19 May 2023; Aviva Stadium, Dublin