Both players are included among the Scottish replacements.
Cammy Mather moves across to openside to allow Jason White to come in at No6.
Nathan Hines comes onto the bench as second row cover.
Scotland
15 Ben Hinshelwood (Worcester)
14 Simon Danielli (Bath Rugby)
*13 Tom Philip (Edinburgh Rugby)
12 Brendan Laney (Edinburgh Rugby)
11 Simon Webster (Edinburgh Rugby)
10 Chris Paterson (Edinburgh Rugby) CAPTAIN
*9 Chris Cusiter (The Borders)
1 Tom Smith (Northampton Saints)
2 Gordon Bulloch (Glasgow Warriors) VICE CAPTAIN
3 Bruce Douglas (The Borders)
4 Scott Murray (Edinburgh Rugby)
5 Stuart Grimes (Newcastle Falcons)
6 Jason White (Sale Sharks)
8 Simon Taylor (Edinburgh Rugby)
7 Cameron Mather (Glasgow Warriors)
Substitutes
16 Robert Russell (Saracens)
17 Gavin Kerr (Leeds Tykes)
18 Nathan Hines (Edinburgh Rugby)
*19 Allister Hogg (Edinburgh Rugby)
*20 Mike Blair (Edinburgh Rugby)
21 Dan Parks (Glasgow Warriors)
22 Andrew Henderson (Glasgow Warriors)
Remaining with the party – Derrick Lee and Simon Cross (both Edinburgh Rugby)
* = member of the Scottish Institute of Sport