Scrum-half Rory Lawson will make his first start following a minor injury to Mike Blair's knee which he sustained in Sunday's win, props Dave Hewett and Craig Smith rejoin the side, as does Francisco Leonelli who will this week start on the left wing in place of Simon Webster, who drops to the bench.
A reaction to an injury sustained by Matt Mustchin on Sunday has opened the door for Simon Cross's return to the team at openside flanker. Allister Hogg switches to the blind side.
Speaking on behalf of the coaching team Todd Blackadder said: "It's a huge chance tomorrow. Glasgow have a good squad and they'll be disappointed with their results so far. They are due a good one.
"We don't see any of the changes as a step backwards. We have the luxury of being in a situation where we can bring players in and know that they are ready for it. It's our first local derby and we're looking forward to playing on Friday night. We were grateful to see all the supporters at Murrayfield on Sunday and we hope to see them back again," he added.
Edinburgh Gunners
15 Hugo Southwell
14 Chris Paterson CAPTAIN
13 Marcus Di Rollo
12 Rob Dewey *
11 Francisco Leonelli
10 Phil Godman
9 Rory Lawson *
1 Dave Hewett
2 Dougie Hall
3 Craig Smith
4 Alastair Kellock *
5 Scott Murray
6 Allister Hogg *
8 Simon Taylor
7 Simon Cross
16 A Kelly *
17 Alasdair Dickinson *
18 Fergus Pringle
19 Alasdair Strokosch *
20 Mike Blair */Jamie Blackwood *
21 Duncan Hodge
22 Simon Webster
* indicates member of the Scottish Institute of Sport
Referee: Simon McDowell (IRFU)
Touch Judges: Peter Allan (SRU), Alistair Cummings (SRU)