Flanker, Jamie Ritchie, centre, Cameron Redpath and winger, Sean Maitland are unavailable through injury.
Scarlets back-row Blade Thomson and Harlequins centre James Lang come into the starting XV, as does Edinburgh winger Darcy Graham. All three played in the last meeting between the two nations, when Scotland beat Wales in Llanelli in October in the concluding round of the 2020 Six Nations competition.
Again, eight Glasgow Warriors are involved - Scott Cummings, Matt Fagerson, Zander Fagerson, George Turner and Ali Price start with Oli Kebble, Richie Gray and Huw Jones on the bench.
Scotland
15 Stuart Hogg CAPTAIN (Exeter Chiefs)
14 Darcy Graham (Edinburgh)
13 Chris Harris (Gloucester)
12 James Lang (Harlequins)
11 Duhan van der Merwe (Edinburgh)
10 Finn Russell VICE CAPTAIN (Racing 92)
9 Ali Price (Glasgow Warriors)
1 Rory Sutherland (Edinburgh)
2 George Turner (Glasgow Warriors)
3 Zander Fagerson (Glasgow Warriors)
4 Scott Cummings (Glasgow Warriors)
5 Jonny Gray VICE CAPTAIN (Exeter Chiefs)
6 Blade Thomson (Scarlets)
7 Hamish Watson (Edinburgh)
8 Matt Fagerson (Glasgow Warriors)
Substitutes
16 David Cherry (Edinburgh)
17 Oli Kebble (Glasgow Warriors)
18 WP Nel (Edinburgh)
19 Richie Gray (Glasgow Warriors)
20 Gary Graham (Newcastle Falcons)
21 Scott Steele (Harlequins)
22 Jaco van der Walt (Edinburgh)
23 Huw Jones (Glasgow Warriors)