An all-Glasgow Warriors front-row sees George Turner return to action after recovering from an injury sustained against Australia a fortnight ago, with the hooker set to win his 20th cap on Saturday afternoon.
The engine room sees Scott Cummings make his return to action after a six-week lay-off following a hand injury picked up against the Sharks, packing down for his first Scotland cap since March's meeting with Ireland.
Ali Price continues at scrum-half for the fifth successive match, having come off the bench for the British and Irish Lions against Japan at BT Murrayfield.
Sam Johnson comes back into the starting XV having missed last weekend's defeat to South Africa, lining up at inside centre as he did in Yokohama.
The replacements see Matt Fagerson move to the bench after three consecutive starts - making more carries than any other Scottish forward last weekend.
George Horne completes the Glasgow contingent, after a 10-minute cameo off the bench last weekend.
The match is live on Amazon Prime Video, with kick-off at 1.00pm on Saturday.
15 Stuart Hogg (Captain) - Exeter
1 Jamie Bhatti - Glasgow Warriors
2 George Turner - Glasgow Warriors
3 Zander Fagerson - Glasgow Warriors
4 Scott Cummings - Glasgow Warriors
5 Grant Gilchrist - Edinburgh Rugby
6 Jamie Ritchie - Edinburgh Rugby
7 Hamish Watson - Edinburgh Rugby
8 Josh Bayliss - Bath Rugby
16 Stuart McInally - Edinburgh Rugby
17 Pierre Schoeman - Edinburgh Rugby
18 Javan Sebastian - Scarlets
19 Sam Skinner - Exeter
20 Dylan Richardson - Cell C Sharks
21 Matt Fagerson - Glasgow Warriors
22 George Horne - Glasgow Warriors
23 Blair Kinghorn - Edinburgh Rugby