It will be the first time that the Scotland international has captained the club, having become a favourite with the Warrior Nation since arriving at Scotstoun back in June 2021.
The 25-year-old will skipper a starting XV showing three changes from last weekend's outing in Swansea, as the Warriors look to extend an unbeaten run at home in the league that stretches back to October 2021.
Sam Johnson lines up alongside captain Tuipulotu in the midfield, a partnership that has developed for both club and country over the past 18 months.
The final change to the starting lineup comes at full-back, as Josh McKay makes his first appearance of the season after recovering from off-season surgery, joining Sebastian Cancelliere and Cole Forbes - who shifts to the wing to accommodate McKay - in the back three.
One further alteration comes amongst the replacements, as Lucio Sordoni - who put pen to paper on a two-year contract with the club earlier this week - replaces Simon Berghan as the cover at tight-head.
The replacements are rounded out by half-back pairing Ali Price and Domingo Miotti - the latter having fond memories of facing the Bulls, having scored twice on his Super Rugby debut against the men from Pretoria during his time at the Jaguares.
Speaking following selection, Franco Smith told glasgowwarriors.org: "We know we welcome a formidable unbeaten Bulls side to Scotstoun tomorrow.
"We will need to take our chances and be more clinical against what will be a of big South African side.
"Sione [Tuipulotu] has been a stand out player for us in the opening rounds and plays a key part in our leadership team in training and on game days. He's passionate about this club and is fully deserving of the honour of leading the team out on Saturday night.
"The Bulls are another opportunity to take a step forward in our journey and everyone at the club is looking forward to welcoming them to Scotstoun tomorrow night."
15 Josh McKay
Unavailable for selection: Allan Dell (calf), Rory Darge (ankle), Jack Dempsey (rib), Jamie Dobie (hamstring), Huw Jones (back), Rufus McLean (hamstring), Ally Miller (back), Enrique Pieretto (shoulder), Kyle Steyn (hamstring) Max Williamson (shoulder).