Four of the new faces come in the back division, with Scotland's record try-scorer Stuart Hogg making a first appearance of the season at full-back and Adam Hastings returning to feature at stand-off against the Flying Fijians.
A new centre partnership sees Chris Harris - who is named as a vice-captain - link up with Cameron Redpath, the latter set to earn a first cap at BT Murrayfield.
Duhan van der Merwe and Darcy Graham are selected at wing, with Ali Price continuing at scrum-half.
The pack has two changes from the side narrowly beaten by Australia last weekend, with Richie Gray returning to the international fold for a first start since 2017 and George Turner coming in at hooker.
Pierre Schoeman packs down with Zander Fagerson either side of Turner, with vice-captain Grant Gilchrist partnering Gray in the second row.
Captain Jamie Ritchie once more leads a back row that also contains Hamish Watson and Matt Fagerson.
Young tighthead prop Murphy Walker is listed among the replacements and the 23-year-old would make his Scotland debut if called upon.
15 Stuart Hogg (Exeter Chiefs) 93 cap
1 Pierre Schoeman (Edinburgh Rugby) 13 caps
2 George Turner (Glasgow Warriors) 28 caps
3 Zander Fagerson (Glasgow Warriors) 51 caps
4 Richie Gray (Glasgow Warriors) 67 caps
5 Grant Gilchrist - Vice Captain - (Edinburgh Rugby) 56 caps
6 Jamie Ritchie - Captain - (Edinburgh Rugby) 33 caps
7 Hamish Watson (Edinburgh Rugby) 52 caps
8 Matt Fagerson (Glasgow Warriors) 25 caps
16 Ewan Ashman (Sale Sharks) 4 caps
17 Rory Sutherland (Ulster Rugby) 20 caps
18 Murphy Walker (Glasgow Warriors) uncapped
19 Jonny Gray (Exeter Chiefs) 69 caps
20 Jack Dempsey (Glasgow Warriors) 1 cap
21 Ben White (London Irish) 6 caps
22 Blair Kinghorn (Edinburgh Rugby) 35 caps
23 Sione Tuipulotu (Glasgow Warriors) 8 caps