Gregor Townsend has made six changes to the team that lost against Fiji last weekend.
In the backs, Kyle Rowe, Kyle Steyn, Fergus Burke and Jamie Dobie all retain their places.
Tom Jordan has been ruled out of the match due to fracturing his hand with Rory Hutchinson and Stafford McDowall taking his and Cameron Redpath's place in the centre.
Arron Reed starts on the wing in place of Darcy Graham, after scoring a try in the win against the Maori All Blacks.
Rory Sutherland and Ewan Ashman will join the British & Irish Lions in Australia on Sunday but will start the match against Samoa in the front row along with Elliot Millar Mills.
Gregor Brown replaces Marshall Sykes in the second row and pairs up with Grant Gilchrist.
Andy Onyeama-Christie returns to the starting line-up alongside tour captain Rory Darge and Matt Fagerson, who completed his return from injury last weekend against Fiji.
In a 6-2 split on the bench, prop Fin Richardson is in line for his first cap having previously donned the blue jersey against the Maori All Blacks. Nathan McBeth and George Turner offer front row options from the bench with Cameron Henderson and Marshall Sykes able to offer support in the second row.
Ben Muncaster has recovered from his leg injury sustained in the first game of tour with George Horne and Adam Hastings also named on the bench.
Former Glasgow prop Aki Seiuli starts for Samoa.
Scotland
15 Kyle Rowe - Glasgow Warriors (13)
14 Kyle Steyn - Glasgow Warriors - VICE-CAPTAIN (24)
13 Rory Hutchinson - Northampton Saints (10)
12 Stafford McDowall - Glasgow Warriors (13)
11 Arron Reed - Sale Sharks (3)
10 Fergus Burke - Saracens (1)
9 Jamie Dobie - Glasgow Warriors (13)
1 Rory Sutherland - Glasgow Warriors (42)
2 Ewan Ashman - Edinburgh Rugby (28)
3 Elliot Millar Mills - Northampton Saints (8)
4 Gregor Brown - Glasgow Warriors (9)
5 Grant Gilchrist - Edinburgh Rugby - VICE-CAPTAIN (81)
6 Andy Onyeama-Christie - Saracens (8)
7 Rory Darge - Glasgow Warriors - CAPTAIN (31)
8 Matt Fagerson - Glasgow Warriors (56)
Substitutes
16 George Turner - Harlequins (46)
17 Nathan McBeth - Glasgow Warriors (2)
18 Fin Richardson - Glasgow Warriors (uncapped)
19 Cameron Henderson - Leicester Tigers (1)
20 Marshall Sykes - Edinburgh Rugby (3)
21 Ben Muncaster - Edinburgh Rugby (2)
22 George Horne - Glasgow Warriors (37)
23 Adam Hastings - Glasgow Warriors (33