Stafford McDowall will captain his country, having assumed the role during the summer match against New Zealand Maori and also against Portugal last November.
McDowall lines up at centre alongside Ollie Smith with Kyle Rowe at full-back.
Jamie Dobie, named as a vice-captain, starts at scrum-half alongside half-back partner Adam Hastings.
In the pack Jack Dempsey features for the first time since the Six Nations. Scott Cummings - also named a vice-captain - is in the second row with Rory Sutherland at loosehead prop.
Front rows Nathan McBeth and Murphy Walker are on the bench, along with Alex Samuel, Max Williamson and George Horne.
Scotland
15 Kyle Rowe - Glasgow Warriors (14)
14 Darcy Graham - Edinburgh Rugby (47)
13 Ollie Smith - Glasgow Warriors (10)
12 Stafford McDowall - Glasgow Warriors (14) - Captain
11 Duhan van der Merwe - Edinburgh Rugby (49)
10 Adam Hastings - Glasgow Warriors (34)
9 Jamie Dobie - Glasgow Warriors (14) - Vice-captain
1 Rory Sutherland - Glasgow Warriors (43)
2 Patrick Harrison - Edinburgh Rugby (3)
3 D'Arcy Rae - Edinburgh Rugby (2)
4 Scott Cummings - Glasgow Warriors (42) - Vice-captain
5 Marshall Sykes - Edinburgh Rugby (4)
6 Liam McConnell - Edinburgh Rugby (uncapped)
7 Dylan Richardson - Edinburgh Rugby (6)
8 Jack Dempsey - Glasgow Warriors (26)
Substitutes
16 Harri Morris - Edinburgh Rugby (uncapped)
17 Nathan McBeth - Glasgow Warriors (3)
18 Murphy Walker - Glasgow Warriors (5)
19 Alex Samuel - Glasgow Warriors (1)
20 Max Williamson - Glasgow Warriors (7)
21 Magnus Bradbury - Edinburgh Rugby (19)
22 George Horne - Glasgow Warriors (38)
23 Ross Thompson - Edinburgh Rugby (5)