Sione Tuipulotu will skipper the team side having been rested for last weekend's 85-0 win over the USA.
He's joined in the back-line by Glasgow Warriors club captain Kyle Steyn, who earns selection on the wing after an impressive start to the 2025/26 URC season.
Up front, Scott Cummings once again features in the engine room, the British & Irish Lion having returned to Scotland action in last weekend's victory over the Americans.
An all-Glasgow Warriors back-row sees Gregor Brown selected at blindside, Matt Fagerson at openside, while Jack Dempsey continues at number eight, following a powerful display at the base of the scrum in the first half of last weekend's run-out.
Rory Sutherland and Jamie Dobie rotate to the bench after starting last Saturday, the latter having picked up Player of the Match honours in addition to his first-ever international hat-trick.
Rory Darge completes the Glasgow cohort selected - the back-rower is set for his first appearance since featuring in the opening URC match of the season.
Scotland
15 Blair Kinghorn - Toulouse (60)
14 Darcy Graham - Edinburgh Rugby (48)
13 Rory Hutchinson - Northampton Saints (9)
12 Sione Tuipulotu - Glasgow Warriors (30) - Captain
11 Kyle Steyn - Glasgow Warriors (25)
10 Finn Russell - Bath Rugby (87) - Vice-captain
9 Ben White - Toulon (29)
1 Pierre Schoeman - Edinburgh Rugby (42)
2 Ewan Ashman - Edinburgh Rugby (29)
3 D'Arcy Rae - Edinburgh Rugby (3)
4 Scott Cummings - Glasgow Warriors (43)
5 Grant Gilchrist - Edinburgh Rugby (82) - Vice-captain
6 Gregor Brown - Glasgow Warriors (10)
7 Matt Fagerson - Glasgow Warriors (57)
8 Jack Dempsey - Glasgow Warriors (27)
Substitutes
16 George Turner - Harlequins (47)
17 Rory Sutherland - Glasgow Warriors (44)
18 Elliot Millar Mills - Northampton Saints (9)
19 Marshall Sykes - Edinburgh Rugby (5)
20 Rory Darge - Glasgow Warriors (32)
21 Josh Bayliss - Bath Rugby (11)
22 Jamie Dobie - Glasgow Warriors (15)
23 Tom Jordan - Bristol Bears (9)