Weir bowed out with a dislocated finger, a torn hamstring, a try and three conversions as Glasgow swept to a 47-10 victory over Zebre on Saturday. The former Scotland fly-half, a two-time league title winner with the club, made his final appearance off the bench - his 163rd in Warriors colours.
By the time Weir crossed for Glasgow's sixth try, the bonus point had already been secured thanks to earlier scores from Stafford McDowall, Ollie Smith, Seb Stephen, Jamie Dobie and Gregor Hiddleston. But his touchdown sparked the loudest roar of the night.
Dobie added a seventh as Warriors climbed to second in the URC table, yet the evening firmly belonged to Weir, who now transitions into a coaching role within the club's academy.
"It's been a really special week," an emotional Weir told Premier Sports. "I've really loved the effort that everyone has put in to reach out and make comments. I'm so grateful. I've lived my dream playing for Glasgow Warriors.
"Going into the coaching side and the academy, I've got all the local talent coming to my doorstep, and my job is to let them live their dream. I'm so hungry for that to be successful - not only for those boys but to keep the evolution of this club going because it's such a special place and I absolutely love it."
Weir marked the occasion with an uncharacteristic supporting line, latching onto a pass from Dobie to score, but paid the price by aggravating a hamstring injury.
"I've never run that line before in my life," the 34-year-old admitted. He could barely walk as the match drew to a close, his bloodied finger heavily strapped, yet he remained on the pitch until the final whistle.
"I don't need to use that hammy any more so we're in a good spot," Weir joked. "But I knew as soon as Dobie gave me the ball and I accelerated, it was gone.
"I tore it maybe four weeks ago now but have just been training through it and pretending it's not there. I tweaked it on a really misty day the week of the Edinburgh game and thought, 'Oh no, that's it, my career's over.' I just did loads of rehab and ignored it.
"I'd do it all again. The other one can go as well - I don't need them any more!"
Head coach Franco Smith was delighted to see Weir sign off in style.
"He hasn't run that cheat line before - he'll probably be saying he should have done it 10 years ago," Smith laughed.
"My joy is for him. He's contributed so much. Even when he hasn't been playing, he's been carrying water for us. His communication and contribution in respect of his new role have already been excellent.
"He's passionate about developing young players and has been a role model and leadership reference point for them for a long time. From a team perspective, you could always rely on him. I often picked him to close games out - he never missed the last penalty. He's just such a professional."