Victory would also see Scotland remain in with a chance of lifting the Guinness Six Nations trophy at the conclusion of Super Saturday, their fate also depending on the result of France's encounter with England in the final match of the triple-header.
Zander Fagerson comes into the front-row to start at tight-head, having come off the bench to impressive effect in last weekend's 50-40 win over France.
Max Williamson starts in the second-row after featuring in each of Scotland's opening three matches in the tournament, following injuries to club-mates Gregor Brown and Scott Cummings.
An all-Glasgow back-row once again sees Jack Dempsey pack down at number eight, flanked by Rory Darge - who leads the competition in turnovers with eight - and Matt Fagerson.
Kyle Steyn has recovered from the leg injury that forced him off the field at Scottish Gas Murrayfield last weekend, as he looks to continue the form that saw him claim two tries and the Player of the Match medal against France.
Huw Jones continues at outside centre, whilst Sione Tuipulotu leads the team from inside centre in their pursuit of silverware.
Rory Sutherland and George Horne are retained on the bench, the former having featured for the first time in the 2026 tournament last Saturday.
The Glasgow cohort is completed by Alex Craig and Kyle Rowe, with both men set for their first involvements in this year's Guinness Six Nations after their impressive form for the Warriors in the 2025/26 season to date.
Scotland
15 Blair Kinghorn - Toulouse (64)
14 Darcy Graham - Edinburgh Rugby (54)
13 Huw Jones - Glasgow Warriors (62)
12 Sione Tuipulotu - Glasgow Warriors (37) - Captain
11 Kyle Steyn - Glasgow Warriors (32)
10 Finn Russell - Bath Rugby (93) Vice-captain
9.Ben White - Toulon (35)
1 Pierre Schoeman - Edinburgh Rugby (48)
2 George Turner - Harlequins (54)
3.Zander Fagerson - Glasgow Warriors (80)
4 Max Williamson - Glasgow Warriors (12)
5 Grant Gilchrist - Edinburgh Rugby (87)
6 Matt Fagerson - Glasgow Warriors (63)
7 Rory Darge - Glasgow Warriors (38) Vice-captain
8 Jack Dempsey - Glasgow Warriors (38)
Substitutes
16 Ewan Ashman - Edinburgh Rugby (34)
17 Rory Sutherland - Glasgow Warriors (47)
18 D'arcy Rae - Edinburgh Rugby (6)
19 Alex Craig - Glasgow Warriors (6)
20 Magnus Bradbury - Edinburgh Rugby (21)
21 George Horne - Glasgow Warriors (44)
22 Kyle Rowe - Glasgow Warriors (16)
23 Tom Jordan - Bristol Bears (16)