Smith has made two changes to the side that defeated Bulls last weekend as his side prepares to host a last-eight tie in Europe's premier club competition for the first time.
Warrior face RC Toulon for the fourth consecutive season as they look to secure a place in the final four.
An unchanged front row sees Patrick Schickerling - one of Glasgow's four try-scorers at Scotstoun last time out - continue at loose-head, packing down alongside Gregor Hiddleston and Zander Fagerson.
Jare Oguntibeju comes into the starting XV to partner Alex Samuel in the second row for the clash with the French heavyweights.
In the back row, Jack Dempsey starts at number eight, with Rory Darge and Matt Fagerson - the top tackler in the Investec Champions Cup so far - completing the loose forward trio.
Behind the scrum, Ben Afshar is named at scrum-half in place of the injured George Horne, linking up with Dan Lancaster in the half-backs.
Last weekend's Player of the Match, Stafford McDowall, retains his place at outside centre, combining once again with Sione Tuipulotu in midfield.
Kyle Steyn captains the side from the wing, with Ollie Smith and Josh McKay completing the back three.
On the bench, Seb Stephen is included in the same week the hooker signed his first professional contract with the Warriors, while Jamie Bhatti and Sam Talakai provide front-row cover.
Max Williamson moves to the bench after starting last time out, joined by Angus Fraser and Euan Ferrie as part of a six-two split between forwards and backs.
The back-line replacements are Adam Hastings and Jack Oliver, with the latter in line to make his debut in the Investec Champions Cup if called upon.
Speaking following selection, Head Coach Smith told glasgowwarriors.org:
"Toulon are well accustomed to knockout matches of this scale, with a proud heritage of success in this competition.
"They have a squad that blends a physical forward pack with a back line that can cause problems for any team, and we know that we must be at our best to meet their challenge.
"The atmosphere at Scotstoun for our European fixtures this season has been second to none, and we know that the Warrior Nation will be behind us all the way again tomorrow afternoon."
15 Josh McKay (76)
14 Kyle Steyn (Captain) (104)
13 Stafford McDowall (111)
12 Sione Tuipulotu (81)
11 Ollie Smith (61)
10 Dan Lancaster (17)
9 Ben Afshar (35)
1 Patrick Schickerling (23)
2 Gregor Hiddleston (42)
3 Zander Fagerson (170)
4 Jare Oguntibeju (18)
5 Alex Samuel (51)
6 Matt Fagerson (137)
7 Rory Darge (76)
8 Jack Dempsey (64)
Substitutes
16 Seb Stephen (15)
17 Jamie Bhatti (134)
18 Sam Talakai (38)
19 Max Williamson (46)
20 Euan Ferrie (53)
21 Angus Fraser (28)
22 Jack Oliver (5)
23 Adam Hastings (86)
Unavailable for selection: Gregor Brown (hamstring), Alex Craig (foot), Scott Cummings (calf), Jamie Dobie (shoulder), George Horne (ankle), Charlie Savala (knee), Tavi Tuipulotu (knee)